CTLA4-Ig interferes and downregulates the proinflammatory activities of rheumatoid synovial macrophages in monoculture

Objective: CTLA4-Ig, a biologic agent employed in rheumatoid arthritis (RA) treatment, downregulates the immune response and exerts anti-inflammatory effects acting on different cells including dendritic/T cells interaction and directly on osteoclasts. We investigated the anti-inflammatory effects o...

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Bibliographic Details
Main Authors: L. Felli, L. Molfetta, P. Clerico, P.F. Triolo, B. Villaggio, B. Seriolo, A. Sulli, P. Montagna, S. Soldano, R. Brizzolara, M. Cutolo
Format: Article
Language:English
Published: PAGEPress Publications 2011-09-01
Series:Reumatismo
Subjects:
Online Access:http://www.reumatismo.org/index.php/reuma/article/view/513