A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation

A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation

In eukaryotic cells, stressors reprogram the cellular proteome by activating the integrated stress response (ISR). In its canonical form, stress-sensing kinases phosphorylate the eukaryotic translation initiation factor eIF2 (eIF2-P), which ultimately leads to reduced levels of ternary complex requi...

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Bibliographic Details
Main Authors: Morgane Boone, Lan Wang, Rosalie E Lawrence, Adam Frost, Peter Walter, Michael Schoof
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-04-01
Series:eLife
Subjects:
eIF2B
ISR
ISRIB
eIF2
allostery
Online Access:https://elifesciences.org/articles/76171

Internet

https://elifesciences.org/articles/76171

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