Evaluation of Pharmacokinetics and Pharmacodynamics of Deferasirox in Pediatric Patients

Evaluation of Pharmacokinetics and Pharmacodynamics of Deferasirox in Pediatric Patients

Background: Deferasirox (DFX) is commonly used to reduce the chronic iron overload (IO) in pediatric patients. However, the drug is characterized by a large pharmacokinetic variability and approximately 10% of patients may discontinue the treatment due to toxicities. Therefore, the present retrospec...

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Bibliographic Details
Main Authors: Laura Galeotti, Francesco Ceccherini, Carmen Fucile, Valeria Marini, Antonello Di Paolo, Natalia Maximova, Francesca Mattioli
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pharmaceutics
Subjects:
Deferasirox
children
population pharmacokinetics
tolerability
therapeutic drug monitoring
Online Access:https://www.mdpi.com/1999-4923/13/8/1238

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https://www.mdpi.com/1999-4923/13/8/1238

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