MK2 Regulates Macrophage Chemokine Activity and Recruitment to Promote Colon Tumor Growth

MK2 Regulates Macrophage Chemokine Activity and Recruitment to Promote Colon Tumor Growth

A major risk factor for colon cancer growth and progression is chronic inflammation. We have shown that the MAPK-activated protein kinase 2 (MK2) pathway is critical for colon tumor growth in colitis-associated and spontaneous colon cancer models. This pathway is known to regulate expression of the...

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Bibliographic Details
Main Authors: Brandon B. Phinney, Anita L. Ray, Amanda S. Peretti, Stephanie J. Jerman, Carl Grim, Irina V. Pinchuk, Ellen J. Beswick
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
MK2
macrophages
chemokines
inflammation
colon tumor
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01857/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01857/full

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