A Personalized Therapeutics Approach Using an In Silico Drosophila Patient Model Reveals Optimal Chemo- and Targeted Therapy Combinations for Colorectal Cancer

A Personalized Therapeutics Approach Using an In Silico Drosophila Patient Model Reveals Optimal Chemo- and Targeted Therapy Combinations for Colorectal Cancer

In silico models of biomolecular regulation in cancer, annotated with patient-specific gene expression data, can aid in the development of novel personalized cancer therapeutic strategies. Drosophila melanogaster is a well-established animal model that is increasingly being employed to evaluate such...

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Bibliographic Details
Main Authors: Mahnoor Naseer Gondal, Rida Nasir Butt, Osama Shiraz Shah, Muhammad Umer Sultan, Ghulam Mustafa, Zainab Nasir, Risham Hussain, Huma Khawar, Romena Qazi, Muhammad Tariq, Amir Faisal, Safee Ullah Chaudhary
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
personalized in silico cancer models
Boolean network models
cancer systems biology
preclinical in silico drug screening
combinatorial therapeutics
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.692592/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.692592/full

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