Ablation of DGKα facilitates α‐smooth muscle actin expression via the Smad and PKCδ signaling pathways during the acute phase of CCl4‐induced hepatic injury

Ablation of DGKα facilitates α‐smooth muscle actin expression via the Smad and PKCδ signaling pathways during the acute phase of CCl4‐induced hepatic injury

Expression of α‐smooth muscle actin (αSMA) is constitutive in vascular smooth muscle cells, but is induced in nonmuscle cells such as hepatic stellate cells (HSCs). HSCs play important roles in both physiological homeostasis and pathological response. HSC activation is characterized by αSMA expressi...

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Bibliographic Details
Main Authors: Keiko Seino, Tomoyuki Nakano, Toshiaki Tanaka, Yasukazu Hozumi, Matthew K. Topham, Kaoru Goto, Ken Iseki
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:FEBS Open Bio
Subjects:
diacylglycerol kinase
hepatic stellate cell
protein kinase C
Smad
α‐smooth muscle actin
Online Access:https://doi.org/10.1002/2211-5463.13749

Internet

https://doi.org/10.1002/2211-5463.13749

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