Aberrant CD8+T cells drive reproductive dysfunction in female mice with elevated IFN-γ levels

Aberrant CD8+T cells drive reproductive dysfunction in female mice with elevated IFN-γ levels

IntroductionInterferon-gamma (IFN-γ) is pivotal in orchestrating immune responses during healthy pregnancy. However, its dysregulation, often due to autoimmunity, infections, or chronic inflammatory conditions, is implicated in adverse reproductive outcomes such as pregnancy failure or infertility....

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Bibliographic Details
Main Authors: Enitome E. Bafor, Rebecca A. Erwin-Cohen, Toni Martin, Clayton Baker, Adrienne E. Kimmel, Olivier Duverger, John M. Fenimore, Meredith Ramba, Thea Spindel, Megan M. Hess, Michael Sanford, Vanja Lazarevic, Bérénice A. Benayoun, Howard A. Young, Julio C. Valencia
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
interferon-gamma (IFN-γ)
CD8+ T cells
hypophysitis
tissue-resident memory
luteinization defect
prolactin deficiency
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1368572/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1368572/full

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