Phototherapeutic Induction of Immunogenic Cell Death and CD8+ T Cell-Granzyme B Mediated Cytolysis in Human Lung Cancer Cells and Organoids

Phototherapeutic Induction of Immunogenic Cell Death and CD8+ T Cell-Granzyme B Mediated Cytolysis in Human Lung Cancer Cells and Organoids

Augmenting T cell mediated tumor killing via immunogenic cancer cell death (ICD) is the cornerstone of emerging immunotherapeutic approaches. We investigated the potential of methylene blue photodynamic therapy (MB-PDT) to induce ICD in human lung cancer. Non-Small Cell Lung Cancer (NSCLC) cell line...

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Bibliographic Details
Main Authors: Asta Valančiūtė, Layla Mathieson, Richard A. O’Connor, Jamie I. Scott, Marc Vendrell, David A. Dorward, Ahsan R. Akram, Kevin Dhaliwal
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cancers
Subjects:
photodynamic therapy
lung cancer
organoids
immunogenic cell death
Online Access:https://www.mdpi.com/2072-6694/14/17/4119

Internet

https://www.mdpi.com/2072-6694/14/17/4119

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