Increased expression of yes-associated protein/YAP and transcriptional coactivator with PDZ-binding motif/TAZ activates intestinal fibroblasts to promote intestinal obstruction in Crohn's disease

Increased expression of yes-associated protein/YAP and transcriptional coactivator with PDZ-binding motif/TAZ activates intestinal fibroblasts to promote intestinal obstruction in Crohn's disease

Background: Intestinal obstruction caused by intestinal fibrosis is a common and serious complication of Crohn's disease (CD). Intestinal fibroblasts, the main effector cells mediating gastrointestinal fibrosis, are activated during chronic inflammation. However, the mechanism of fibroblast act...

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Bibliographic Details
Main Authors: Weijun Ou, Weimin Xu, Fangyuan Liu, Yuegui Guo, Zhenyu Huang, Tienan Feng, Chen-Ying Liu, Peng Du
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:EBioMedicine
Subjects:
Crohn's disease
intestinal fibroblasts
YAP
TAZ
ROCK1
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421002450

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http://www.sciencedirect.com/science/article/pii/S2352396421002450

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