Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces

Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces

Manufacturing parameters may have a strong impact on the dissolution and disintegration of solid dosage forms. In line with process analytical technology (PAT) and quality by design approaches, computer-based technologies can be used to design, control, and improve the quality of pharmaceutical comp...

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Bibliographic Details
Main Authors: Reiji Yokoyama, Go Kimura, Christian M. Schlepütz, Jörg Huwyler, Maxim Puchkov
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Pharmaceutics
Subjects:
drug release simulation
disintegration simulation
poorly water-soluble drug
mefenamic acid
Noyes-Whitney equation
cellular automata
synchrotron microtomography
Online Access:https://www.mdpi.com/1999-4923/10/4/259

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https://www.mdpi.com/1999-4923/10/4/259

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