A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis

A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis

Summary: The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely unexplored. Here, we identify NR4A1 as a target of the Hippo pathway that mediates the pro-apoptotic and an...

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Bibliographic Details
Main Authors: Lingli He, Liang Yuan, Wentao Yu, Yang Sun, Dan Jiang, Xiaodong Wang, Xue Feng, Zuoyun Wang, Jinjin Xu, Ruizeng Yang, Wenxiang Zhang, Hua Feng, Hang-zi Chen, Yi Arial Zeng, Lijian Hui, Qiao Wu, Yonglong Zhang, Lei Zhang
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Cell Reports
Subjects:
Hippo signaling pathway
NR4A1
apoptosis
liver regeneration
hepatocellular carcinoma (HCC)
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720312730

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http://www.sciencedirect.com/science/article/pii/S2211124720312730

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