Crystal structure of the α-ketoglutarate-dependent non-heme iron oxygenase CmnC in capreomycin biosynthesis and its engineering to catalyze hydroxylation of the substrate enantiomer

Crystal structure of the α-ketoglutarate-dependent non-heme iron oxygenase CmnC in capreomycin biosynthesis and its engineering to catalyze hydroxylation of the substrate enantiomer

CmnC is an α-ketoglutarate (α-KG)-dependent non-heme iron oxygenase involved in the formation of the l-capreomycidine (l-Cap) moiety in capreomycin (CMN) biosynthesis. CmnC and its homologues, VioC in viomycin (VIO) biosynthesis and OrfP in streptothricin (STT) biosynthesis, catalyze hydroxylation o...

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Bibliographic Details
Main Authors: Yu-Hsuan Hsiao, Szu-Jo Huang, En-Chi Lin, Po-Yun Hsiao, Shu-Ing Toh, I-Hsuan Chen, Zhengren Xu, Yu-Pei Lin, Hsueh-Ju Liu, Chin-Yuan Chang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Chemistry
Subjects:
capreomycin
non-heme iron oxygenase
hydroxylation
engineering
D-Arg
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.1001311/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.1001311/full

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