Validation of a UHPLC-MS/MS Method to Quantify Twelve Antiretroviral Drugs within Peripheral Blood Mononuclear Cells from People Living with HIV

Validation of a UHPLC-MS/MS Method to Quantify Twelve Antiretroviral Drugs within Peripheral Blood Mononuclear Cells from People Living with HIV

Recently, anti-HIV treatment has achieved high efficacy and tolerability. Nevertheless, few data are available about the intracellular penetration of antiretrovirals, partly due to the technical challenges related to intracellular quantification. This work aimed to validate an ultra-high performance...

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Bibliographic Details
Main Authors: Amedeo De Nicolò, Alice Ianniello, Micol Ferrara, Valeria Avataneo, Jessica Cusato, Miriam Antonucci, Elisa De Vivo, Catriona Waitt, Andrea Calcagno, Alice Trentalange, Giampiero Muccioli, Stefano Bonora, Giovanni Di Perri, Antonio D'Avolio
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Pharmaceuticals
Subjects:
liquid chromatography
tandem mass spectrometry
peripheral blood mononuclear cells
dolutegravir
intracellular
Online Access:https://www.mdpi.com/1424-8247/14/1/12

Internet

https://www.mdpi.com/1424-8247/14/1/12

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