Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice

Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice

<p>Abstract</p> <p>Background</p> <p>Abnormal distribution, modification and aggregation of transactivation response DNA-binding protein 43 (TDP-43) are the hallmarks of multiple neurodegenerative diseases, especially frontotemporal lobar degeneration with ubiquitin-pos...

Full description

Bibliographic Details
Main Authors: Dickson Dennis W, Stetler Caroline, Cao Xiangkun, Lin Wen-Lang, Zhang Yong-Jie, Xu Ya-Fei, Lewis Jada, Petrucelli Leonard
Format: Article
Language:English
Published: BMC 2011-10-01
Series:Molecular Neurodegeneration
Subjects:
aggregation
ALS
mitochondria
mouse model
tau
Online Access:http://www.molecularneurodegeneration.com/content/6/1/73

Internet

http://www.molecularneurodegeneration.com/content/6/1/73

Similar Items