Platelet Factor 4 Attenuates Experimental Acute Liver Injury in Mice

Platelet Factor 4 Attenuates Experimental Acute Liver Injury in Mice

Platelet factor 4 (PF4) is a pleiotropic inflammatory chemokine, which has been implicated in various inflammatory disorders including liver fibrosis. However, its role in acute liver diseases has not yet been elucidated. Here we describe an unexpected, anti-inflammatory role of PF4. Serum concentra...

Full description

Bibliographic Details
Main Authors: Hannah K. Drescher, Elisa F. Brandt, Petra Fischer, Stephan Dreschers, Reto A. Schwendener, M. Anna Kowalska, Ali Canbay, Hermann E. Wasmuth, Ralf Weiskirchen, Christian Trautwein, Marie-Luise Berres, Daniela C. Kroy, Hacer Sahin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Physiology
Subjects:
hepatoprotective effects
PF4
liver
acute liver damage
macrophages
activated protein C
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00326/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00326/full

Similar Items