Engrailed 1 mediates correct formation of limb innervation through two distinct mechanisms.
Engrailed-1 (En1) is expressed in the ventral ectoderm of the developing limb where it plays an instructive role in the dorsal-ventral patterning of the forelimb. Besides its well-described role as a transcription factor in regulating gene expression through its DNA-binding domain, En1 may also be s...
| Autors principals: | , , , , , , |
|---|---|
| Format: | Article |
| Idioma: | English |
| Publicat: |
Public Library of Science (PLoS)
2015-01-01
|
| Col·lecció: | PLoS ONE |
| Accés en línia: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0118505&type=printable |