Neurokinin-2 receptor negatively modulates substance P responses by forming complex with Neurokinin-1 receptor

Neurokinin-2 receptor negatively modulates substance P responses by forming complex with Neurokinin-1 receptor

Abstract Background Tachykinins and their cognate receptors, neurokinin receptors (NKs) including NK1, NK2, and NK3 play vital roles in regulating various physiological processes including neurotransmission, nociception, inflammation, smooth muscle contractility, and stimulation of endocrine and exo...

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Bibliographic Details
Main Authors: Lan Phuong Nguyen, Minyeong Cho, Thai Uy Nguyen, Hee-Kyung Park, Huong Thi Nguyen, Kateryna Mykhailova, Sunghoon Hurh, Hong-Rae Kim, Jae Young Seong, Cheol Soon Lee, Byung-Joo Ham, Jong-Ik Hwang
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Cell & Bioscience
Subjects:
Neurokinin receptors
GPCR dimerization
Negative modulation
Calcium signaling
ERK phosphorylation
β-arrestin
Online Access:https://doi.org/10.1186/s13578-023-01165-6

Internet

https://doi.org/10.1186/s13578-023-01165-6

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