Aflibercept Off-Target Effects in Diabetic Macular Edema: An In Silico Modeling Approach

Aflibercept Off-Target Effects in Diabetic Macular Edema: An In Silico Modeling Approach

Intravitreal aflibercept injection (IAI) is a treatment for diabetic macular edema (DME), but its mechanism of action (MoA) has not been completely elucidated. Here, we aimed to explore IAI’s MoA and its multi-target nature in DME pathophysiology with an in silico (computer simulation) disease model...

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Bibliographic Details
Main Authors: Morgane Blanot, Ricardo Pedro Casaroli-Marano, Jordi Mondéjar-Medrano, Thaïs Sallén, Esther Ramírez, Cristina Segú-Vergés, Laura Artigas
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
intravitreal aflibercept injection
systems biology
vascular endothelial growth factor
inflammation
oxidative stress
angiogenesis
Online Access:https://www.mdpi.com/1422-0067/25/7/3621

Internet

https://www.mdpi.com/1422-0067/25/7/3621

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