Molecular characterisation of atypical BSE prions by mass spectrometry and changes following transmission to sheep and transgenic mouse models.

Molecular characterisation of atypical BSE prions by mass spectrometry and changes following transmission to sheep and transgenic mouse models.

The prion hypothesis proposes a causal relationship between the misfolded prion protein (PrPSc) molecular entity and the disease transmissible spongiform encephalopathy (TSE). Variations in the conformation of PrPSc are associated with different forms of TSE and different risks to animal and human h...

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Bibliographic Details
Main Authors: Adriana Gielbert, Jemma K Thorne, Jane M Plater, Leigh Thorne, Peter C Griffiths, Marion M Simmons, Claire A Cassar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6224059?pdf=render

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http://europepmc.org/articles/PMC6224059?pdf=render

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