Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives

Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives

New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for basal cytotoxicity on the following human cell...

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Bibliographic Details
Main Authors: Guillermo Schmeda-Hirschmann, Daniel Droguett, Paulo González, Francisco Monsalve, Erdem Yesilada, Maria del Mar Afonso, Cristina Theoduloz, Jose Antonio Palenzuela, Mariano Walter Pertino
Format: Article
Language:English
Published: MDPI AG 2011-10-01
Series:Molecules
Subjects:
labdane diterpenes
lapachol derivatives
diterpenylnaphthoquinones
gastroprotection
basal cytotoxicity
Online Access:http://www.mdpi.com/1420-3049/16/10/8614/

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http://www.mdpi.com/1420-3049/16/10/8614/

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