Dynamic Perturbations of CD4 and CD8 T Cell Receptor Repertoires in Chronic Hepatitis B Patients upon Oral Antiviral Therapy

Dynamic Perturbations of CD4 and CD8 T Cell Receptor Repertoires in Chronic Hepatitis B Patients upon Oral Antiviral Therapy

Long-term treatment with nucleos(t)ide analogs (NUCs) can improve the antiviral T cell response in chronic hepatitis B (CHB) patients. Whether and to what extent the T cell response is improved by NUCs in the early stage leading to hepatitis B e antigen (HBeAg) seroconversion remain to be clarified....

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Bibliographic Details
Main Authors: Ying Xu, Yu Liu, Miaoxian Zhao, Yunqing Chen, Cantao Xie, Mingxing Gong, Haohui Deng, Xueying Li, Jian Sun, Jinlin Hou, Hongkai Wu, Zhanhui Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
high-throughput sequencing
chronic hepatitis B infection
nucleos(t)ide analogs
hepatitis B e antigen seroconversion
T cell receptor
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01142/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.01142/full

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