Micheliolide Enhances Radiosensitivities of p53-Deficient Non-Small-Cell Lung Cancer via Promoting HIF-1α Degradation

Micheliolide Enhances Radiosensitivities of p53-Deficient Non-Small-Cell Lung Cancer via Promoting HIF-1α Degradation

Micheliolide (MCL) has shown promising anti-inflammatory and anti-tumor efficacy. However, whether and how MCL enhances the sensitivity of non-small-cell lung cancer (NSCLC) to radiotherapy are still unknown. In the present paper, we found that MCL exerted a tumor cell killing effect on NSCLC cells...

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Bibliographic Details
Main Authors: Peizhong Kong, K.N. Yu, Miaomiao Yang, Waleed Abdelbagi Almahi, Lili Nie, Guodong Chen, Wei Han
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
micheliolide
radiosensitizer
hypoxia-inducible factor-1α
vascular endothelial growth factor
p53
Online Access:https://www.mdpi.com/1422-0067/21/9/3392

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https://www.mdpi.com/1422-0067/21/9/3392

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