Heparin-conjugated injectable hydrogels with sustained releasing capability for promotion of H-type vessels formation and rat femoral bone defects repair

Heparin-conjugated injectable hydrogels with sustained releasing capability for promotion of H-type vessels formation and rat femoral bone defects repair

Adequate vascularization is crucial for the repair of bone defects. Platelet-derived growth factor-BB (PDGF-BB) has been shown to promote H-type vessel formation, a specialized blood vessel, strongly positive for CD31 and endomucin, coupling angiogenesis and osteogenesis. However, the lack of a cont...

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Bibliographic Details
Main Authors: Jianguo Wei, Dongming Duan, Yihan Jing, Shuai Huang, Jiamin Liu, Aiju Lou, Tianhua Xiao, Yapei Chen, Xia Chen, Yuwei Zeng, Song Liu, Zhao Wang, Yixi Yang, Lei Zhou, Zenghui Wu, Le Wang
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Materials & Design
Subjects:
Platelet derived growth factor-BB
Injectable hydrogels
Femoral condyle defect
H-type blood vessels
Vascularized bone regeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0264127523008225

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http://www.sciencedirect.com/science/article/pii/S0264127523008225

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