NADPH and Mitochondrial Quality Control as Targets for a Circadian-Based Fasting and Exercise Therapy for the Treatment of Parkinson’s Disease

NADPH and Mitochondrial Quality Control as Targets for a Circadian-Based Fasting and Exercise Therapy for the Treatment of Parkinson’s Disease

Dysfunctional mitochondrial quality control (MQC) is implicated in the pathogenesis of Parkinson’s disease (PD). The improper selection of mitochondria for mitophagy increases reactive oxygen species (ROS) levels and lowers ATP levels. The downstream effects include oxidative damage, failure to main...

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Bibliographic Details
Main Authors: William M. Curtis, William A. Seeds, Mark P. Mattson, Patrick C. Bradshaw
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
Parkinson’s disease
mitochondrial quality control
NADPH
DJ-1
PINK1
Parkin
Online Access:https://www.mdpi.com/2073-4409/11/15/2416

Internet

https://www.mdpi.com/2073-4409/11/15/2416

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