<i>Pcsk6</i> Deficiency Promotes Cardiomyocyte Senescence by Modulating Ddit3-Mediated ER Stress

<i>Pcsk6</i> Deficiency Promotes Cardiomyocyte Senescence by Modulating Ddit3-Mediated ER Stress

Cardiac aging is a critical determinant of cardiac dysfunction, which contributes to cardiovascular disease in the elderly. Proprotein convertase subtilisin/kexin 6 (PCSK6) is a proteolytic enzyme important for the maintenance of cardiac function and vascular homeostasis. To date, the involvement of...

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Bibliographic Details
Main Authors: Wenxing Zhan, Liping Chen, Hongfei Liu, Changkun Long, Jiankun Liu, Shuangjin Ding, Qingyu Wu, Shenghan Chen
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Genes
Subjects:
cardiomyocytes
DDIT3
ER stress
PCSK6
senescence
Online Access:https://www.mdpi.com/2073-4425/13/4/711

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https://www.mdpi.com/2073-4425/13/4/711

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