Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy.

Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy.

The development of a safe and effective AD vaccine requires a delicate balance between providing an adequate anti-Abeta antibody response sufficient to provide therapeutic benefit, while eliminating an adverse T cell-mediated proinflammatory autoimmune response. To achieve this goal we have designed...

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Bibliographic Details
Main Authors: Nina Movsesyan, Anahit Ghochikyan, Mikayel Mkrtichyan, Irina Petrushina, Hayk Davtyan, Purevdorj B Olkhanud, Elizabeth Head, Arya Biragyn, David H Cribbs, Michael G Agadjanyan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2358976?pdf=render

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http://europepmc.org/articles/PMC2358976?pdf=render

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