Using graph-based model to identify cell specific synthetic lethal effects

Using graph-based model to identify cell specific synthetic lethal effects

Synthetic lethal (SL) pairs are pairs of genes whose simultaneous loss-of-function results in cell death, while a damaging mutation of either gene alone does not affect the cell’s survival. This makes SL pairs attractive targets for precision cancer therapies, as targeting the unimpaired gene of the...

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Bibliographic Details
Main Authors: Mengchen Pu, Kaiyang Cheng, Xiaorong Li, Yucui Xin, Lanying Wei, Sutong Jin, Weisheng Zheng, Gongxin Peng, Qihong Tang, Jielong Zhou, Yingsheng Zhang
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Synthetic lethality
GNN
Deep learning
Cell specific target identification
Multi-omics
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023003641

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http://www.sciencedirect.com/science/article/pii/S2001037023003641

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