Yeast as a Model to Unravel New BRCA2 Functions in Cell Metabolism

Yeast as a Model to Unravel New BRCA2 Functions in Cell Metabolism

Mutations in BRCA2 gene increase the risk for breast cancer and for other cancer types, including pancreatic and prostate cancer. Since its first identification as an oncosupressor in 1995, the best-characterized function of BRCA2 is in the repair of DNA double-strand breaks (DSBs) by homologous rec...

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Bibliographic Details
Main Authors: Alessandra Costanza, Nicoletta Guaragnella, Antonella Bobba, Caterina Manzari, Alberto L’Abbate, Claudio Lo Giudice, Ernesto Picardi, Anna Maria D’Erchia, Graziano Pesole, Sergio Giannattasio
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
BRCA2
metabolic reprogramming
yeast
RNA seq
mitochondrial dysfunction
mitochondrial retrograde pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.908442/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.908442/full

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