Glutamine Availability Controls BCR/Abl Protein Expression and Functional Phenotype of Chronic Myeloid Leukemia Cells Endowed with Stem/Progenitor Cell Potential

Glutamine Availability Controls BCR/Abl Protein Expression and Functional Phenotype of Chronic Myeloid Leukemia Cells Endowed with Stem/Progenitor Cell Potential

This study was directed to characterize the role of glutamine in the modulation of the response of chronic myeloid leukemia (CML) cells to low oxygen, a main condition of hematopoietic stem cell niches of bone marrow. Cells were incubated in atmosphere at 0.2% oxygen in the absence or the presence o...

Full description

Bibliographic Details
Main Authors: Martina Poteti, Giulio Menegazzi, Silvia Peppicelli, Ignazia Tusa, Giulia Cheloni, Angela Silvano, Caterina Mancini, Alessio Biagioni, Alessandro Tubita, Nathalie M. Mazure, Matteo Lulli, Elisabetta Rovida, Persio Dello Sbarba
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
chronic myeloid leukemia
low oxygen
glutamine
glucose
stem cell niche
minimal residual disease
Online Access:https://www.mdpi.com/2072-6694/13/17/4372

Internet

https://www.mdpi.com/2072-6694/13/17/4372

Similar Items