Knockout of Anopheles stephensi immune gene LRIM1 by CRISPR-Cas9 reveals its unexpected role in reproduction and vector competence.

Knockout of Anopheles stephensi immune gene LRIM1 by CRISPR-Cas9 reveals its unexpected role in reproduction and vector competence.

PfSPZ Vaccine against malaria is composed of Plasmodium falciparum (Pf) sporozoites (SPZ) manufactured using aseptically reared Anopheles stephensi mosquitoes. Immune response genes of Anopheles mosquitoes such as Leucin-Rich protein (LRIM1), inhibit Plasmodium SPZ development (sporogony) in mosquit...

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Bibliographic Details
Main Authors: Ehud Inbar, Abraham G Eappen, Robert T Alford, William Reid, Robert A Harrell, Maryam Hosseini, Sumana Chakravarty, Tao Li, B Kim Lee Sim, Peter F Billingsley, Stephen L Hoffman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-11-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009770

Internet

https://doi.org/10.1371/journal.ppat.1009770

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