Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations

Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations

Uterine adenomyosis often co-occurs with endometriosis or leiomyoma, but little is known about its molecular underpinnings. Here, the authors show that KRAS mutations are frequent in this disease, which might reduce sensitivity to progestin treatment via epigenetic silencing of the progesterone rece...

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Bibliographic Details
Main Authors: Satoshi Inoue, Yasushi Hirota, Toshihide Ueno, Yamato Fukui, Emiko Yoshida, Takuo Hayashi, Shinya Kojima, Reina Takeyama, Taiki Hashimoto, Tohru Kiyono, Masako Ikemura, Ayumi Taguchi, Tomoki Tanaka, Yosuke Tanaka, Seiji Sakata, Kengo Takeuchi, Ayako Muraoka, Satoko Osuka, Tsuyoshi Saito, Katsutoshi Oda, Yutaka Osuga, Yasuhisa Terao, Masahito Kawazu, Hiroyuki Mano
Format: Article
Language:English
Published: Nature Portfolio 2019-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13708-y

Internet

https://doi.org/10.1038/s41467-019-13708-y

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