Integration of the Salmonella Typhimurium Methylome and Transcriptome Reveals That DNA Methylation and Transcriptional Regulation Are Largely Decoupled under Virulence-Related Conditions

Integration of the Salmonella Typhimurium Methylome and Transcriptome Reveals That DNA Methylation and Transcriptional Regulation Are Largely Decoupled under Virulence-Related Conditions

ABSTRACT Despite being in a golden age of bacterial epigenomics, little work has systematically examined the plasticity and functional impacts of the bacterial DNA methylome. Here, we leveraged single-molecule, real-time sequencing (SMRT-seq) to examine the m6A DNA methylome of two Salmonella enteri...

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Bibliographic Details
Main Authors: Jeffrey S. Bourgeois, Caroline E. Anderson, Liuyang Wang, Jennifer L. Modliszewski, Wei Chen, Benjamin H. Schott, Nicolas Devos, Dennis C. Ko
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:mBio
Subjects:
DNA methylation
Salmonella
gene regulation
m6A
methylome
transcription
Online Access:https://journals.asm.org/doi/10.1128/mbio.03464-21

Internet

https://journals.asm.org/doi/10.1128/mbio.03464-21

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