Deficiency of GntR Family Regulator MSMEG_5174 Promotes Mycobacterium smegmatis Resistance to Aminoglycosides via Manipulating Purine Metabolism

Deficiency of GntR Family Regulator MSMEG_5174 Promotes Mycobacterium smegmatis Resistance to Aminoglycosides via Manipulating Purine Metabolism

The increasing incidence of drug-resistant tuberculosis is still an emergency for global public health and a major obstacle to tuberculosis treatment. Therefore, deciphering the novel mechanisms of mycobacterial antibiotic resistance is crucial for combatting the rapid emergence of drug-resistant st...

Full description

Bibliographic Details
Main Authors: Wanyan Deng, Zengzhang Zheng, Yi Chen, Maoyi Yang, Jun Yan, Wu Li, Jie Zeng, Jianping Xie, Sitang Gong, Huasong Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Microbiology
Subjects:
Mycobacterium smegmatis
GntR
MSMEG_5174
purine metabolism
aminoglycoside antibiotics resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.919538/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.919538/full

Similar Items