In vitro toxic evaluation of two gliptins and their main impurities of synthesis

In vitro toxic evaluation of two gliptins and their main impurities of synthesis

Abstract Background The presence of impurities in some drugs may compromise the safety and efficacy of the patient’s treatment. Therefore, establishing of the biological safety of the impurities is essential. Diabetic patients are predisposed to tissue damage due to an increased oxidative stress pro...

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Bibliographic Details
Main Authors: Camila F. A. Giordani, Sarah Campanharo, Nathalie R. Wingert, Lívia M. Bueno, Joanna W. Manoel, Barbara Costa, Shanda Cattani, Marcelo Dutra Arbo, Solange Cristina Garcia, Cássia Virginia Garcia, Nádia Maria Volpato, Elfrides Eva Scherman Schapoval, Martin Steppe
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Pharmacology and Toxicology
Subjects:
Sitagliptin
Vildagliptin
Drug impurities
Cytotoxicity
Oxidative stress
Online Access:https://doi.org/10.1186/s40360-019-0354-2

Internet

https://doi.org/10.1186/s40360-019-0354-2

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