Swinhoeic acid from Potentilla fragarioides ameliorates high glucose-induced oxidative stress and accumulation of ECM in mesangial cells via Keap1-dependent activation of Nrf2

Swinhoeic acid from Potentilla fragarioides ameliorates high glucose-induced oxidative stress and accumulation of ECM in mesangial cells via Keap1-dependent activation of Nrf2

Objectives Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes mellitus. Oxidative stress resulting from high glucose promotes accumulation of ECM and development of DN. Activation of Nrf2 could attenuate oxidative stress and following accumulation of ECM. To...

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Bibliographic Details
Main Authors: Huankai Yao, Min Kong, Dan Du, Fengwei Ai, Jindong Li, Yan Li
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Redox Report
Subjects:
Swinhoeic acid
diabetic nephropathy
mesangial cells
high glucose
self-limited proliferation
oxidative stress
Online Access:https://www.tandfonline.com/doi/10.1080/13510002.2022.2134755

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https://www.tandfonline.com/doi/10.1080/13510002.2022.2134755

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