The SARS‐CoV‐2 main protease (Mpro): Structure, function, and emerging therapies for COVID‐19

The SARS‐CoV‐2 main protease (Mpro): Structure, function, and emerging therapies for COVID‐19

Abstract The main proteases (Mpro), also termed 3‐chymotrypsin‐like proteases (3CLpro), are a class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has demonstrated that 3CLpros play an indispensable role in viral replication and have been recognized as key targets fo...

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Bibliographic Details
Main Authors: Qing Hu, Yuan Xiong, Guang‐Hao Zhu, Ya‐Ni Zhang, Yi‐Wen Zhang, Ping Huang, Guang‐Bo Ge
Format: Article
Language:English
Published: Wiley 2022-09-01
Series:MedComm
Subjects:
3‐chymotrypsin‐like protease (3CLpro)
broad‐spectrum anti‐coronavirus agents
SARS‐CoV‐2
β‐coronavirus 3CLpro inhibitor
Online Access:https://doi.org/10.1002/mco2.151

Internet

https://doi.org/10.1002/mco2.151

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