ERK5 inhibitor BIX02189 attenuates methamphetamine-induced hyperactivity by modulating microglial activation in the striatum

Extracellular signal-regulated protein kinase 5 (ERK5) has various physiological functions. However, the physiological role of ERK5 in the treatment of mice with an illicit drug such as methamphetamine (METH) remains unknown. We revealed that mice treated with METH showed hyperactivity, and increase...

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Bibliographic Details
Main Authors: Osamu Nakagawasai, Kohei Takahashi, Yuki Miura, Wataru Nemoto, Yutaro Obara, Koichi Tan-No
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Journal of Pharmacological Sciences
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861322000093