Intimate intertwining of the pathogenesis of hypoxia and systemic sclerosis: A transcriptome integration analysis

Intimate intertwining of the pathogenesis of hypoxia and systemic sclerosis: A transcriptome integration analysis

ObjectivesSystemic sclerosis (SSc) is an autoimmune disease caused by various pathogenic factors, including hypoxia. Hypoxia stimulates the production of the extracellular matrix to promote fibrosis. However, the integrated function and the underlying mechanism of hypoxia in SSc are unclear.MethodsI...

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Bibliographic Details
Main Authors: Xinglan He, Yaqian Shi, Zhuotong Zeng, Bingsi Tang, Xuan Xiao, Jiangfan Yu, Puyu Zou, Jiani Liu, Yangfan Xiao, Yangyang Luo, Rong Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
hypoxia
systemic sclerosis
oxidative stress
PPI
crosstalk
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.929289/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.929289/full

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