The process of EDC-NHS cross-linking of reconstituted collagen fibres increases collagen fibrillar order and alignment

We describe the production of collagen fibre bundles through a multi-strand, semi-continuous extrusion process. Cross-linking using an EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide), NHS (N-hydroxysuccinimide) combination was considered. Atomic Force Microscopy and Raman spectroscopy focused on...

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Bibliographic Details
Main Authors: D. V. Shepherd, J. H. Shepherd, S. Ghose, S. J. Kew, R. E. Cameron, S. M. Best
Format: Article
Language:English
Published: AIP Publishing LLC 2015-01-01
Series:APL Materials
Online Access:http://dx.doi.org/10.1063/1.4900887