Blocking Ubiquitin‐Specific Protease 7 Induces Ferroptosis in Gastric Cancer via Targeting Stearoyl‐CoA Desaturase

Blocking Ubiquitin‐Specific Protease 7 Induces Ferroptosis in Gastric Cancer via Targeting Stearoyl‐CoA Desaturase

Abstract Gastric cancer (GC) presents a formidable global health challenge, and conventional therapies face efficacy limitations. Ubiquitin‐specific protease 7 (USP7) plays pivotal roles in GC development, immune response, and chemo‐resistance, making it a promising target. Various USP7 inhibitors h...

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Bibliographic Details
Main Authors: Xiaoqing Guan, Yichao Wang, Wenkai Yu, Yong Wei, Yang Lu, Enyu Dai, Xiaowu Dong, Bing Zhao, Can Hu, Li Yuan, Xin Luan, Kai Miao, Bonan Chen, Xiang‐Dong Cheng, Weidong Zhang, Jiang‐Jiang Qin
Format: Article
Language:English
Published: Wiley 2024-05-01
Series:Advanced Science
Subjects:
ferroptosis
gastric cancer
SCD
ubiquitination
USP7
USP7 inhibitor
Online Access:https://doi.org/10.1002/advs.202307899

Internet

https://doi.org/10.1002/advs.202307899

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