Influence of the Position and Composition of Radiometals and Radioiodine Labels on Imaging of Epcam Expression in Prostate Cancer Model Using the DARPin Ec1

Influence of the Position and Composition of Radiometals and Radioiodine Labels on Imaging of Epcam Expression in Prostate Cancer Model Using the DARPin Ec1

The epithelial cell adhesion molecule (EpCAM) is intensively overexpressed in 40–60% of prostate cancer (PCa) cases and can be used as a target for the delivery of drugs and toxins. The designed ankyrin repeat protein (DARPin) Ec1 has a high affinity to EpCAM (68 pM) and a small size (18 kDa). Radio...

Full description

Bibliographic Details
Main Authors: Sergey M. Deyev, Tianqi Xu, Yongsheng Liu, Alexey Schulga, Elena Konovalova, Javad Garousi, Sara S. Rinne, Maria Larkina, Haozhong Ding, Torbjörn Gräslund, Anna Orlova, Vladimir Tolmachev, Anzhelika Vorobyeva
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
radionuclide
EpCAM
DARPin
PET
SPECT
imaging
Online Access:https://www.mdpi.com/2072-6694/13/14/3589

Internet

https://www.mdpi.com/2072-6694/13/14/3589

Similar Items