PD1-CD28 Fusion Protein Enables CD4+ T Cell Help for Adoptive T Cell Therapy in Models of Pancreatic Cancer and Non-hodgkin Lymphoma

PD1-CD28 Fusion Protein Enables CD4+ T Cell Help for Adoptive T Cell Therapy in Models of Pancreatic Cancer and Non-hodgkin Lymphoma

Background: Interaction of the programmed death receptor 1 (PD-1) and its ligand, PD-L1, suppresses T cell activity and permits tumors to evade T cell-mediated immune surveillance. We have recently demonstrated that antigen-specific CD8+ T cells transduced with a PD1-CD28 fusion protein are protecte...

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Bibliographic Details
Main Authors: Felicitas Rataj, Fabian B. T. Kraus, Michael Chaloupka, Simon Grassmann, Constanze Heise, Bruno L. Cadilha, Peter Duewell, Stefan Endres, Sebastian Kobold
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
adoptive T cell transfer
cancer immunotherapy
costimulation
PD-1-CD28 fusion protein
CD4+ T cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01955/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01955/full

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