Identification of tissue-specific and common methylation quantitative trait loci in healthy individuals using MAGAR

Identification of tissue-specific and common methylation quantitative trait loci in healthy individuals using MAGAR

Abstract Background Understanding the influence of genetic variants on DNA methylation is fundamental for the interpretation of epigenomic data in the context of disease. There is a need for systematic approaches not only for determining methylation quantitative trait loci (methQTL), but also for di...

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Bibliographic Details
Main Authors: Michael Scherer, Gilles Gasparoni, Souad Rahmouni, Tatiana Shashkova, Marion Arnoux, Edouard Louis, Arina Nostaeva, Diana Avalos, Emmanouil T. Dermitzakis, Yurii S. Aulchenko, Thomas Lengauer, Paul A. Lyons, Michel Georges, Jörn Walter
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Epigenetics & Chromatin
Subjects:
Quantitative trait loci
DNA methylation
Tissue specificity
Computational biology
Online Access:https://doi.org/10.1186/s13072-021-00415-6

Internet

https://doi.org/10.1186/s13072-021-00415-6

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