Mitochondrial Peroxiredoxin 3 Is Rapidly Oxidized and Hyperoxidized by Fatty Acid Hydroperoxides

Mitochondrial Peroxiredoxin 3 Is Rapidly Oxidized and Hyperoxidized by Fatty Acid Hydroperoxides

Human peroxiredoxin 3 (<i>Hs</i>Prx3) is a thiol-based peroxidase responsible for the reduction of most hydrogen peroxide and peroxynitrite formed in mitochondria. Mitochondrial disfunction can lead to membrane lipoperoxidation, resulting in the formation of lipid-bound fatty acid hydrop...

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Bibliographic Details
Main Authors: Giuliana Cardozo, Mauricio Mastrogiovanni, Ari Zeida, Nicolás Viera, Rafael Radi, Aníbal M. Reyes, Madia Trujillo
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Antioxidants
Subjects:
peroxiredoxin
mitochondria
fatty acid hydroperoxide
lipid peroxidation
antioxidant systems
kinetics
Online Access:https://www.mdpi.com/2076-3921/12/2/408

Internet

https://www.mdpi.com/2076-3921/12/2/408

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