Downregulation of kainate receptors regulating GABAergic transmission in amygdala after early life stress is associated with anxiety-like behavior in rodents

Downregulation of kainate receptors regulating GABAergic transmission in amygdala after early life stress is associated with anxiety-like behavior in rodents

Abstract Early life stress (ELS) is a well-characterized risk factor for mood and anxiety disorders. GABAergic microcircuits in the amygdala are critically implicated in anxiety; however, whether their function is altered after ELS is not known. Here we identify a novel mechanism by which kainate re...

Full description

Bibliographic Details
Main Authors: Jonas Englund, Joni Haikonen, Vasilii Shteinikov, Shyrley Paola Amarilla, Tsvetomira Atanasova, Alexandra Shintyapina, Maria Ryazantseva, Juha Partanen, Vootele Voikar, Sari E. Lauri
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01654-7

Internet

https://doi.org/10.1038/s41398-021-01654-7

Similar Items