Identification of Amino Acid Residues in Angiotensin II Type 1 Receptor Sensing Mechanical Stretch and Function in Cardiomyocyte Hypertrophy

Identification of Amino Acid Residues in Angiotensin II Type 1 Receptor Sensing Mechanical Stretch and Function in Cardiomyocyte Hypertrophy

Background/Aims: Angiotensin II (AngII) type 1 receptor (AT1R) could be activated by mechanical stress without the involvement of AngII during the development of cardiac hypertrophy. We aimed to identify sensing sites of AT1R for activation by mechanical stretch. Methods: We constructed several site...

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Bibliographic Details
Main Authors: Guoliang Jiang, Hui Gong, Yuhong Niu, Chunjie Yang, Shijun Wang, Zhidan Chen, Yong Ye, Ning Zhou, Guoping Zhang, Junbo Ge, Yunzeng Zou
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
AT1R
Mechanical stress
Angiotensin II
Sensitive sites
Cardiac hypertrophy
Online Access:http://www.karger.com/Article/FullText/430337

Internet

http://www.karger.com/Article/FullText/430337

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