Sphingoid Bases Regulate the Sigma-1 Receptor—Sphingosine and <i>N</i>,<i>N</i>’-Dimethylsphingosine Are Endogenous Agonists

Sphingoid Bases Regulate the Sigma-1 Receptor—Sphingosine and <i>N</i>,<i>N</i>’-Dimethylsphingosine Are Endogenous Agonists

Both bioactive sphingolipids and Sigma-1 receptor (S1R) chaperones occur ubiquitously in mammalian cell membranes. Endogenous compounds that regulate the S1R are important for controlling S1R responses to cellular stress. Herein, we interrogated the S1R in intact Retinal Pigment Epithelial cells (AR...

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Bibliographic Details
Main Authors: Jing Li, Kenneth A. Satyshur, Lian-Wang Guo, Arnold E. Ruoho
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
sigma-1 receptor
endogenous agonists
sphingosine
<i>N</i>,<i>N</i>’-dimethylsphingosine
modified native gel approach
molecular docking
Online Access:https://www.mdpi.com/1422-0067/24/4/3103

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https://www.mdpi.com/1422-0067/24/4/3103

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