Sphingoid Bases Regulate the Sigma-1 Receptor—Sphingosine and <i>N</i>,<i>N</i>’-Dimethylsphingosine Are Endogenous Agonists
Both bioactive sphingolipids and Sigma-1 receptor (S1R) chaperones occur ubiquitously in mammalian cell membranes. Endogenous compounds that regulate the S1R are important for controlling S1R responses to cellular stress. Herein, we interrogated the S1R in intact Retinal Pigment Epithelial cells (AR...
Main Authors: | Jing Li, Kenneth A. Satyshur, Lian-Wang Guo, Arnold E. Ruoho |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-02-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/24/4/3103 |
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