Juvenile idiopathic arthritis fibroblast-like synoviocytes influence chondrocytes to alter BMP antagonist expression demonstrating an interaction between the two prominent cell types involved in endochondral bone formation

Juvenile idiopathic arthritis fibroblast-like synoviocytes influence chondrocytes to alter BMP antagonist expression demonstrating an interaction between the two prominent cell types involved in endochondral bone formation

Abstract Background To examine critical interactions between juvenile idiopathic arthritis synovial fibroblasts (JFLS) and chondrocytes (Ch), and their role in bony overgrowth seen in patients with juvenile idiopathic arthritis (JIA). Methods Control (CFLS) and JFLS were cultured in synoviocyte medi...

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Bibliographic Details
Main Authors: Megan M. Simonds, Amanda R. Schlefman, Suzanne M. McCahan, Kathleen E. Sullivan, Carlos D. Rose, AnneMarie C. Brescia
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Pediatric Rheumatology Online Journal
Subjects:
Fibroblast
Synoviocyte
Chondrocyte
TGFβ
BMP4
BMP antagonists
Online Access:http://link.springer.com/article/10.1186/s12969-020-00483-0

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http://link.springer.com/article/10.1186/s12969-020-00483-0

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