Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein

Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein

Alpha-1-antitrypsin (AAT) deficiency results from misfolding-prone AAT variants. Here the authors show that AAT forms co-translational folding intermediates on the ribosome that persist upon release and determine its folding fate. They show too that the ribosome can also modulate misfolding-prone AA...

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Bibliographic Details
Main Authors: Elena Plessa, Lien P. Chu, Sammy H. S. Chan, Oliver L. Thomas, Anaïs M. E. Cassaignau, Christopher A. Waudby, John Christodoulou, Lisa D. Cabrita
Format: Article
Language:English
Published: Nature Portfolio 2021-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-26531-1

Internet

https://doi.org/10.1038/s41467-021-26531-1

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